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Title of Journal: Int J Clin Oncol

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Abbravation: International Journal of Clinical Oncology

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Springer Japan

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DOI

10.1007/s12129-008-9071-9

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ISSN

1437-7772

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A prospective randomized placebocontrolled tria

Authors: Mohamed S Zaghloul Rimoun Boutrus Hisham ElHossieny Yasser Abdel Kader Inas ElAttar Mohamed Nazmy
Publish Date: 2010/04/01
Volume: 15, Issue: 4, Pages: 382-389
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Abstract

Zoledronic acid treatment reduces the incidence of skeletalrelated events SREs in patients with bone metastases from breast lung and urologic cancers including prostate and renal cancer The aim of this study was to evaluate the effect of zoledronic acid on SREs in patients with bone metastases from bladder cancerThe patients n = 40 were evenly distributed between the two treatment groups and the baseline demographics of the two groups were similar The followup varied from 8 to 65 weeks median 24 weeks Compared with patients receiving placebo those receiving zoledronic acid had a lower mean incidence of SREs 205 ± 10 vs 095 ± 09 respectively and a larger proportion did not experience an onstudy SRE 2 vs 8 patients respectively Zoledronic acid also prolonged the median time to first SRE compared with the placebo 16 vs 8 weeks respectively Multiple event analysis of SREs revealed that zoledronic acid decreased the risk of SRE development by 59 hazard ratio 0413 Zoledronic acid also increased the 1year survival rate compared with placebo 363 ± 112 vs 0 respectively Zoledronic acid was generally well tolerated in our patient population

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