Authors: JiaFu Feng Ling Lu Ping Zeng YunHong Yang Jun Luo YuWei Yang Dong Wang
Publish Date: 2011/10/05
Volume: 17, Issue: 6, Pages: 575-583
Abstract
Oxidative stress and trace elements have been implicated in the development of breast cancer However how they contribute to the pathogenesis of the disease and the relationship between them remain unclear In addition most previous studies detecting one or a few oxidant/antioxidant markers failed to consider the overall oxidant/antioxidant status of the subjects This study was designed to address this and to investigate the association between oxidative status and trace elements in the pathogenesis of breast cancerFiftysix patients with breast carcinoma at different clinical stages 32 patients with benign breast tumor and 20 healthy subjects controls were recruited into this study Their serum total antioxidant status TAS total oxidant status TOS oxidative stress index OSI and levels of Cu Zn Fe Se Mg and Mn were measuredLevels of TAS TOS OSI and trace elements significantly differed between the study groups Among subgroups of patients with different clinical stages of breast cancer the levels of all the trace elements except Zn were similar whereas TAS TOS and OSI levels were all significantly different There were significant correlations between oxidative stress parameters and levels of trace elements in patients with breast carcinoma but not in patients with benign breast tumor or in the healthy controls
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