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Title of Journal: Invest New Drugs

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Abbravation: Investigational New Drugs

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Springer US

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DOI

10.1007/jhep01(2012)165

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1573-0646

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Blackberryinduced handfoot skin reaction to suni

Authors: Susan L Boone Gayle Jameson Daniel Von Hoff Mario E Lacouture
Publish Date: 2008/11/08
Volume: 27, Issue: 4, Pages: 389-390
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Abstract

Sunitinib is an orally administered small molecule that was approved by the US Food and Drug Administration in January 2006 as monotherapy for the treatment of patients with advanced renal cell carcinoma RCC and patients with gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate Data pooled from multiple sunitinib doseescalation trials showed that sunitinib is associated with various adverse events with HFSR occurring in up to 20 of patients We describe a 48yearold woman with a history of metastatic colorectal cancer treated with singleagent sunitinib who developed pain and tenderness in areas of friction secondary to Blackberry use and was diagnosed with traumainduced handfoot skin reaction HFSR secondary to sunitinib therapy

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