Journal Title
Title of Journal: Invest New Drugs
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Abbravation: Investigational New Drugs
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Authors: Danilo D Rocha Aruna Balgi Ana Isabel V Maia Otilia D Pessoa Edilberto R Silveira Letícia V CostaLotufo Michel Roberge Claudia Pessoa
Publish Date: 2011/03/18
Volume: 30, Issue: 3, Pages: 959-966
Abstract
Many compounds used in the treatment of cancer possess tubulininteracting properties that lead to mitotic arrest Withaphysalins are potent cytotoxic compounds that are commonly found in plants belonging to the Solanaceae family such as Acnistus arborescens however the cytotoxic mechanisms or molecular targets of these compounds remain unknown Thus the aim of this study was to evaluate the effects of whitaphysalins on cancer cell cycle progression and tubulin interaction In this report we show the antiproliferative activity of withaphysalin F and its effect in arresting cells in the G2/M phase of the cell cycle These two effects are the result of the interference of withaphysalin F in the polymerization of microtubules Withaphysalin F also induced DNA fragmentation which can be related to an increase in mitochondrial membrane depolarization These results suggest that interference of withaphysalin F in microtubule polymerization may induce cell cycle arrest in the G2/M phase and therefore contribute to growth inhibition of tumor cells in vitro Taken together these studies indicate that withaphysalin F could potentially be used as an anticancer drug
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