Journal Title
Title of Journal: Cell Tissue Bank
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Abbravation: Cell and Tissue Banking
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Publisher
Springer Netherlands
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Authors: K Stephen Suh Yvonne K Remache Jalpa S Patel Steve H Chen Russell Haystrand Peggy Ford Anadil M Shaikh Jian Wang Andre H Goy
Publish Date: 2008/11/19
Volume: 10, Issue: 1, Pages: 43-48
Abstract
Modern cancer research for biomarker discovery program requires solving several tasks that are directly involved with patient sample procurement One requirement is to construct a highly efficient workflow on the clinical side for the procurement to generate a consistent supply of high quality samples for research This undertaking needs a network of interdepartmental collaborations and participations at various levels including physical human interactions information technology implementations and a bioinformatics tool that is highly effective and userfriendly to busy clinicians and researchers associated with the sample procurement Collegial participation that is sequential but continual from one department to another demands dedicated bioinformatics software coordinating between the institutional clinic and the tissue repository facility Participants in the process include admissions consenting process phlebotomy surgery center and pathology During this multiple step procedures clinical data are collected for detailed analytical endpoints to supplement logistics of defining and validating the discovery of biomarkersWorking with highquality human tumor and tissue samples is essential for advancement of biomarker discovery program in modern cancer research Bast et al 2005 For this purpose tissue repository or tumor banks are in need for research institutions specializing in collecting human biomaterials and making them available for a wide array of research community at the level of institution national or global Several issues regarding the tissue repository facilities are currently undergoing refinements to maintain high quality clinical samples1 2 Ericsson et al 2006 Some of the major problematic issues involved in the sample acquisition or procurement processes that are recognized by scientific communities and institutions are sample preparation regulatory compliance van Veen 2006 storage and processing To use these samples in research institutional studies and collaborations need to be evaluated by the institutional review board IRB and conform to Health Insurance Portability and Accountability Act HIPAA
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