Journal Title
Title of Journal: Cell Tissue Bank
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Abbravation: Cell and Tissue Banking
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Publisher
Springer Netherlands
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Authors: Laura Visser Eleonoor Holsboer Arlinke G Bokhorst Marja J van Wijk
Publish Date: 2010/09/17
Volume: 13, Issue: 1, Pages: 37-46
Abstract
Directive 2006/17/EC requires that all available medical information including autopsy reports is evaluated before releasing tissues for transplantation The aim of this study was to investigate whether evaluation of results of autopsy and other histological examinations contributes to the safety of tissue transplantation From the files of all deceased Dutch donors from whom tissues were retrieved in a 6month period results of autopsy and other histological examinations remnant heart after valve donation and biopsies obtained during retrieval were evaluated for contraindications for transplantation Of 758 donors at least one tissue was considered suitable for transplantation at initial assessment 637 Donors donated corneas 256 skin 177 heart valves and 61 musculoskeletal tissues On 220 donors 290 autopsy was done Of seven donors no autopsy results were requested since a contraindication was detected earlier in the medical screening In 19 donors with autopsy 89 general or tissuespecific contraindications were detected There were no differences in distribution of detected contraindications among donors who donated different tissues For 136 donors 179 results of histological examinations other than autopsy were available results of examination of remnant hearts for all brain autopsy for two 03 and retrieval biopsy for four donors 05 Contraindications were detected in nine of these donors with histology results other than autopsy 66 For 402 donors 53 no histological examinations were done Evaluation of results of autopsy and other histological examinations improves the safety of tissue transplantation for all types of tissues In donors without autopsy alternative histological examinations can contribute to enhance the safety of tissue transplantation
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