Authors: Roger F Butterworth
Publish Date: 2008/12/06
Volume: 24, Issue: 1, Pages: 189-196
Abstract
Endstage chronic liver failure results in thiamine deficiency caused principally by depletion of liver thiamine stores Chronic liver failure also leads to increased brain ammonia concentrations Both ammonia and thiamine deficiency result in decreased activity of αketoglutarate dehydrogenase a ratelimiting tricarboxylic acid cycle enzyme Loss of enzyme activity results in a mitochondrial oxidative deficit in brain and consequent increases in brain lactate oxidative/nitrosative stress cellular energy impairment and release of proinflammatory cytokines all of which have been described in brain in endstage chronic liver failure Synergistic effects of ammonia exposure and thiamine deficiency could explain the diencephalic and cerebellar symptomatology described in patients with “hepatic encephalopathy” Unsuspected brain lesions due to thiamine deficiency could explain the incomplete resolution of neuropsychiatric symptoms following the use of ammonialowering agents or liver transplantation in patients with endstage chronic liver failure These findings underscore the need for prompt effective thiamine supplementation in all patients with chronic liver failure
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