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Title of Journal: Metab Brain Dis

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Abbravation: Metabolic Brain Disease

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Springer US

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DOI

10.1016/0300-5712(87)90109-6

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1573-7365

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Intracerebral hemorrhage in mouse models therapeu

Authors: Balachandar Kathirvelu S Thomas Carmichael
Publish Date: 2014/05/10
Volume: 30, Issue: 2, Pages: 449-459
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Abstract

There has been strong preclinical research on mechanisms of initial cell death and tissue injury in intracerebral hemorrhage ICH This data has led to the evaluation of several therapeutics for neuroprotection or the mitigation of early tissue damage Most of these studies have been done in the rat Also there has been little study of the mechanisms of tissue repair and recovery This review examines the testing of candidate therapeutics in mouse models of ICH for their effect on tissue protection and repair This review will help the readers compare it to the extensively researched rat model of ICH and thus enhance work that are pending in mouse model

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