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Title of Journal: Metab Brain Dis

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Abbravation: Metabolic Brain Disease

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Springer US

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DOI

10.1007/s00216-011-5674-z

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1573-7365

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Circadian variations in behaviors BDNF and cell p

Authors: LiTao Yi Liu Luo YongJing Wu BinBin Liu XiaoLong Liu Di Geng Qing Liu
Publish Date: 2015/07/18
Volume: 30, Issue: 6, Pages: 1495-1503
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Abstract

Neurotrophic factors are wellknown to be involved in the pathophysiology of depression and treatment of antidepressants Brainderived neurotrophic factor BDNF one of the most widely distributed and the most highly studied neurotrophic factors has been demonstrated to play an important role in the pathophysiology of depression and the mechanism of antidepressants According to the previous studies we found that animal tissues were dissected for BDNF measurement mainly in daytime Considering the circadian rhythm of BDNF expression our present study evaluated the circadian variations in behaviors serum corticosterone concentrations hippocampal BDNF expression and neuronal cell proliferation in mice exposed to chronic mild stress CMS one of the most widely used depressionlike animal models Our results provided the first evidence that the difference of BDNF expression and neuronal cell proliferation between CMS and control mice underwent an oscillation related to the circadian variations maximum at 2000 h minimum at 1200 h or 1600 h while the difference of sucrose preference and first feeding latency was not affected by circadian rhythm This oscillation difference was attributed to the relative constant BDNF expression and cell proliferation in CMS mice and the fluctuating BDNF expression and cell proliferation in control mice CMS exposure might destroy the circadian rhythm of BDNF expression and cell proliferation in hippocampus of normal individual Our present study suggests that animal decapitation at 2000 h is the best time for BDNFrelated measurement in CMS experiment since the difference reaches the maximumThe project was supported by grants from the National Natural Science Foundation of China No 81202940 the Science Research Foundation of ministry of Health United Fujian Provincial Health and Education Project for Tacking the Key Research WKJFJ31 the Promotion Program for Young and Middleaged Teacher in Science and Technology Research of Huaqiao University ZQNPY218 and the Outstanding Youth Scientific Research Training Program in Colleges and Universities of Fujian Province JA14015

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