Correlation between degree and quality of sleep di

Authors: Jayanta Samanta Radha K Dhiman Amit Khatri Kiran K Thumburu Sandeep Grover Ajay Duseja Yogesh Chawla

Publish Date: 2013/03/15

Volume: 28, Issue: 2, Pages: 249-259

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Abstract

Sleep disturbances are common in patients of cirrhosis and has a significant effect on their health related quality of life HRQOL Thus far no study has demonstrated a systematically studied significant correlation between the sleep disturbance observed and the neuropsychiatric impairment status of patients of cirrhosis On the basis of PHES we divided 100 cirrhotics into those having minimal hepatic encephalopathy MHE PHES≤−5 and those not NMHE Now in these MHE n=46 and NMHE n=54 patients sleep disturbance was measured with Pittsburgh Sleep Quality Index PSQI and Epworth Sleepiness Scale ESS and HRQOL with SF36v2 questionnaire Sixty 60  patients were found to be ‘poor sleepers’ PSQI5 while 38 38  patients had excessive daytime sleepiness ESS≥11 Univariate and multivariate analyses showed MHE has significant effect among ‘poor sleepers’ P00001 as well as on those with EDS P00001 Significant correlation existed between PHES and both the sleep parameters of PSQI r = −0518 P 00001 as well as ESS r = −0383 P 00001 implying independently strong correlation between poor cognition and the presence of night time sleep disturbance and excessive daytime sleepiness among cirrhotics Significant correlation existed between PSQI and ESS and the various scales and component scores of SF36v2 signifying the negative impact of sleep disturbance on the HRQOL In conclusion both night time sleep disturbance and excessive daytime sleepiness have significant relation with the neuropsychiatric impairment in patients of cirrhosis and are significantly associated with the observed impairment in HRQOL

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