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Title of Journal: Genetica

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Abbravation: Genetica

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Springer Netherlands

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1573-6857

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Molecular evolution of Emphasis Type="Italic"PKD

Authors: Chun Ye Huan Sun Wenhu Guo Yuquan Wei Qin Zhou
Publish Date: 2009/02/01
Volume: 137, Issue: 1, Pages: 77-86
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Abstract

PKD2 gene encodes a critical cation channel protein that plays important roles in various developmental processes and is usually evolutionarily conserved In the present study we analyzed the evolutionary patterns of PKD2 and its homologous genes PKD2L1 PKD2L2 from nine mammalian species In this study we demonstrated the orthologs of PKD2 gene family evolved under a dominant purifying selection force Our results in combination with the reported evidences from functional researches suggested the entire PKD2 gene family are conserved and perform essential biological roles during mammalian evolution In rodents PKD2 gene family members appeared to have evolved more rapidly than other mammalian lineages probably resulting from relaxation of purifying selection However positive selection imposed on synonymous sites also potentially contributed to this case For the paralogs our results implied that PKD2L2 genes evolved under a weaker purifying selection constraint than PKD2 and PKD2L1 genes Interestingly some loop regions of transmembrane domain of PKD2L2 exhibited higher P N/P S ratios than expected suggesting these regions are more functional divergent in organisms and worthy of special attentionThis work was supported by a grant of the National Key Basic Research Program of China to Prof Qin Zhou 2005CB522506 and a grant of the National Key Basic Research Program of China to academician Yuquan Wei 2004CB518800 The work was also supported by a grant of the ST Bureau of Sichuan Province to Qin Zhou


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