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Title of Journal: Lung

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Abbravation: Lung

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Springer-Verlag

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10.1002/bs.3830250307

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1432-1750

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Levels of Transferrin in Bronchoalveolar Lavage Fl

Authors: Masahiko Shigemura Yasuyuki Nasuhara Satoshi Konno Takeshi Hattori Chikara Shimizu Kazuhiko Matsuno Masaharu Nishimura
Publish Date: 2010/01/12
Volume: 188, Issue: 2, Pages: 151-157
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Abstract

There has been only one report showing high levels of transferrin Tf in bronchoalveolar lavage fluid BALF in patients with sarcoidosis This study was designed to assess the levels of Tf in both BALF and serum and to examine the relationship between the levels of Tf and other disease markers in sarcoidosis Subjects were 64 sarcoidosis and 10 healthy controls Tf in BALF and serum was measured by nephelometric assay Median Tf levels in BALF from sarcoidosis was 070 range 000–397 mg/dl which was significantly higher compared with controls 036 range 000–102 mg/dl p = 0005 In contrast median Tf levels in serum from sarcoidosis was 258 range 171–383 mg/dl which was significantly lower compared with controls 322 range 234–356 mg/dl p = 0003 Tf levels in BALF were significantly correlated with both the percentage of lymphocytes r = 0617 p = 0001 and serum angiotensinconverting enzyme activity r = 0363 p = 0003 and serum soluble interleukin2 receptor r = 0450 p = 0001 in sarcoidosis Levels of Tf in BALF from patients with sarcoidosis were not influenced by smoking status The levels of Tf in sarcoidosis are high in BALF but low in serum Increased levels of Tf in BALF may reflect the disease activity

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