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Title of Journal: Lung

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Abbravation: Lung

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Springer US

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10.1002/chin.201521183

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1432-1750

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COPD and Thyroid Dysfunctions

Authors: Claudio Terzano S Romani G Paone V Conti F Oriolo
Publish Date: 2013/11/27
Volume: 192, Issue: 1, Pages: 103-109
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Abstract

Chronic obstructive pulmonary COPD is one of the major causes of morbidity and mortality in the world COPD is characterized by chronic inflammation in the pulmonary compartment and in the systemic circulation This disorder is associated with clinically significant alterations in biochemistry and organ function thyroid dysfunctions are common in chronic diseases such as COPD Several characteristics of COPD patients could increase their likelihood of developing hypothyroidism or hyperthyroidism The purpose of our study was to assess the impact of thyroid dysfunction in patients with COPDWe evaluated the pulmonary function tests arterial blood gases maximal inspiratory pressure MIP maximal expiratory pressure MEP and thyroid functions in patients with COPD recruited between admissions in Respiratory Diseases Unit Policlinico Umberto I Rome Italy from June 2012 to May 2013 We selected patients with subclinical hypothyroidism ScH overt hypothyroidism and hyperthyroidism and a control group without thyroid disturbanceOur results indicate that patients with overt hypothyroidism have lower levels of pO2 MIP and MEP compared with subjects with ScH hyperthyroidism and the control group We also found a substantial tendency towards pCO2 levels increase in patients with hypothyroidism p = 006Patients with thyroid dysfunctions have a greater impairment of MIP and MEP and a negative correlation was observed between hypoxemia and TSH Further studies are needed to investigate whether the treatment of thyroid disfunction could have a beneficial effect on COPD patients’ lung function and prognosis

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