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Title of Journal: Lung

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Abbravation: Lung

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Springer US

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DOI

10.1002/chin.201525256

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1432-1750

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Profile of Metalloproteinases and Their Associatio

Authors: Lisete Ribeiro Teixeira Murilo B Dias Roberta K B Sales Leila Antonangelo Vanessa A Alvarenga Juliana Puka Evaldo Marchi Milena Marques Pagliarelli Acencio
Publish Date: 2016/09/27
Volume: 194, Issue: 6, Pages: 1021-1027
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Abstract

Matrix metalloproteinases MMPs are responsible for the breakdown of the extracellular matrix and play an important role in the inflammatory processes of pleural exudates The imbalance between MMPs and their inhibitors TIMPs is present in various pathological processesThe patients with pleural effusion due to tuberculosis TB cancer CA or transudate were prospectively evaluated Pleural fluid was submitted to cytological biochemical cytokines MMP and TIMP analysis Statistical analysis was performed using ANOVA and Spearman’s correlation and p  005 was considered significantOne hundred and fourteen patients were enrolled 80 exudates 41 TB and 39 CA and 34 transudates The levels of MMP8 and MMP9 were higher in exudates compared to transudates The level of MMP8 was significantly higher in TB than in CA TIMP1 levels were higher in exudates IL6 VEGF and TGFβ1 showed differences between exudates and transudates However IL6 level was higher in TB than in CA We found a significant correlation between MMPs and TIMPs with inflammation markers MMP1 was correlated with LDH levels MMP8 was correlated with LDH total cell count neutrophils and ADA as well as MMP1 levels MMP9 was correlated with IL6 TGFβ1 and VEGF TIMP1 was correlated with MMP9 and IL6MMPs and TIMPs are expressed in pleural fluid of different etiologies and correlate with inflammatory mediators MMPs may be useful in determining the cause of fluid but more studies are needed to determine the spectrum of diseases associated with the various isoforms of MMPS and TIMPsWe thank the physicians Leandro H Yoshioka and Marcelo FA Silva for their assistance with date and references The financial support provided by the Research Support Foundation of the State of São Paulo FAPESP and The National Research Council CNPq Brazil is acknowledged

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