Pineal–adrenal–immune system relationship under th

Authors: Veerasamy Sejian Rajendra Swaroop Srivastava

Publish Date: 2010/08/17

Volume: 66, Issue: 4, Pages: 339-349

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Abstract

The purpose of the investigation was to observe the pineal–adrenal–immune system relationships and their influence on nonspecific immune response in female goats under shortterm thermal stress Six female goats had been exposed to 40°C and 60 relative humidity in the psychrometric chamber for 17 days Blood samples were obtained on days 0 and 10 to establish control and thermal stress effects respectively Chemical adrenalectomy was achieved by injecting metyrapone 100 mg/kg body weight followed by exogenous melatonin treatment 01 mg/kg body weight from 11th to 17th day of experiment Thermal stress significantly P ≤ 005 altered the physiological responses Metyrapone and melatonin treatment significantly P ≤ 005 reduced the thermalstressinduced increase in plasma concentrations of cortisol and corticosterone while significantly P ≤ 005 increased the plasma melatonin on days 11 and 17 Furthermore these treatments significantly P  005 increased the phagocytic activity of neutrophils as compared to both control and thermal exposure values from 11–17 days of experiment The data generated from this study help us to understand the functional relationship between pineal adrenal and immune system and how this relationship modifies the nonspecific immune response for the well being of goats during thermal stress

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