Diurnal rhythms of plasma GLP1 levels in normal a

Authors: Joaquín Santiago Galindo Muñoz Diana Jiménez Rodríguez Juan José Hernández Morante

Publish Date: 2014/12/28

Volume: 71, Issue: 1, Pages: 17-28

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Abstract

Food intake is regulated by not only neurohormonal but also social educational and even cultural factors Within the former there is a complex interaction between orexigenic ghrelin and anorexigenic glucagonlike peptide1 GLP1 factors in order to adjust the food intake to caloric expenditure however the number of subjects that are unable to properly balance appetite and body weight is increasing continuously A loss of circadian or diurnal coordination of any of these factors may be implied in this situation Special attention has retrieved GLP1 due to its usefulness as a therapeutic agent against obesity and related alterations Thus the objective of the present study was to compare GLP1 diurnal synthesis between normal weight and overweight/obese subjects and to evaluate whether weight loss can restore the synthesis rhythms of GLP1 Three groups of 25 subjects were divided attending to their body mass index BMI in normal weight overweight or obese subjects Diurnal 5 points GLP1 levels were analyzed Secondly an intervention behavioraldietary treatment study was conducted to analyze the effect of weight loss on plasma GLP1 concentrations Our results showed that baseline GLP1 level was significantly lower in normal weight subjects p = 0003 furthermore our cosinor analysis revealed a higher amplitude p = 0040 and daily GLP1 variation 47  in these subjects In fact our ANOVA data showed a lack of rhythmicity in overweight/obese patients Weight loss was not able to restore a diurnal rhythm of plasma GLP1 levels In summary the present work shows a disruption of diurnal GLP1 levels in overweight/obese subjects which worsen as body fat progresses The attenuation of the GLP1 synthesis rhythms may be important to understand the impairment of food intake regulation in overweight/obese subjectsWe would like to thank the psychologists Magdalena Gomez and Rosario Gomez for their assistance in the psychological and behavioral treatment of overweight and obese patients of the present study We also want to thank Rubén Cañavate for his assistance in the language editing of the manuscript The authors have no conflicts of interest to declare The present work was funded by PMAFI/14/12 project from the Support for Research Help Program of the Catholic University of Murcia

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