Changes in serum parameters associated with iron m

Authors: Minoo Moshtaghie Pedram Malekpouri Mohammad Reza Dinko Ali Asghar Moshtaghie

Publish Date: 2012/09/25

Volume: 69, Issue: 2, Pages: 297-304

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Abstract

Due to the severe hazardous influences of lead Pb2+ on ironrelated diseases the effects of Pb2+ on serum parameters associated with iron metabolism have been studied in this project Male Wistar rats weighing 200–250 g were treated with Pb2+ for the short and long period of times The animals received daily intraperitoneal injection of 100 mg Pb2+ kg−1 body weight BW for 5 days and 4 mg kg−1 BW of Pb2+ for 30 and 45 days respectively The results show that when animals were treated with both low and high concentrations of Pb2+ serum iron concentration decreased markedly by 232 328 and 399  while the sera TIBC and transferrin concentrations increased significantly p  005 Following short and longterm exposures to Pb2+ the percentage of serum transferrin saturation was also decreased in comparison with the untreated control group p  005 Concentrations of serum copper and ceruloplasmin following Pb2+ treatments also reduced significantly p  005 The percentage of hematocrit and hemoglobin levels was reduced p  005 in all Pb2+treated animals in comparison with the controls These results suggest that Pb2+ changes the serum parameters related to iron metabolism which may play an important role in producing ironrelated diseases

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