Authors: Kursad Turksen
Publish Date: 2011/04/28
Volume: 7, Issue: 4, Pages: 797-798
Abstract
It is now believed that most epithelial tumors are maintained by a subpopulation of cells called cancer stem cells CSCs or tumor initiating cells TICs with stem celllike properties including selfrenewal and multilineage differentiation capacity Recently new insights into this population have emerged in certain epithelial tumor types including their Claudinlow phenotype and its importance to the epithelialmesenchymal transition EMT process Taken together CSCs EMT and Claudins appear to constitute an axisofevil in cancer for which better understanding may lead to new therapeutic platforms
Keywords: