PrePregnancy Body Mass Index and Weight Gain Duri

Authors: B Heude O Thiébaugeorges V Goua A Forhan M Kaminski B Foliguet M Schweitzer G Magnin M A Charles The EDEN Mother–Child Cohort Study Group

Publish Date: 2011/01/22

Volume: 16, Issue: 2, Pages: 355-363

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Abstract

To study the relationship between prepregnancy body mass index BMI and weight gain during pregnancy with pregnancy and birth outcomes with a focus on gestational diabetes and hypertension and their role in the association with fetal growth We studied 1884 mothers and offspring from the Eden mother–child cohort Weight before pregnancy W1 and weight after delivery W2 were collected and we calculated BMI and net gestational weight gain netGWG = W2 − W1/weeks of gestation Gestational diabetes hypertension gestational age and birth weight were collected We used multivariate linear or logistic models to study the association between BMI netGWG and pregnancy and birth outcomes adjusting for center maternal age and height parity and average number of cigarettes smoked per day during pregnancy High BMI was more strongly related to the risk of giving birth to a largeforgestationalage LGA baby than high netGWG odds ratio OR 95 CI of 323 186–560 and 161 091–285 respectively However after excluding mothers with gestational diabetes or hypertension the ORs for LGA respectively weakened OR 257 129–513 for obese women and strengthened for high netGWG OR 208 114–380 Low in comparison to normal netGWG had an OR of 218 120–399 for preterm birth which became stronger after accounting for blood pressure and glucose disorders OR 270 137–534 Higher net gestational weight gain was significantly associated with an increased risk of LGA only after accounting for blood pressure and glucose disorders High gestational weight gain should not be neglected in regard to risk of LGA in women without apparent risk factorsThe EDEN Mother–Child Study group M A Charles M de Agostini A Forhan B Heude P Ducimetière M Kaminski M J SaurelCubizolles P Dargent X Fritel B Larroque N Lelong L Marchand C Nabet I AnnesiMaesano R Slama V Goua G Magnin R Hankard O Thiebaugeorges M Schweitzer B Foliguet and N JobSpiraEthics Approval The study was approved by the ethics committee CCPPRB of Kremlin Bicêtre and by the Data Protection Authority “Comission Nationale de l’Informatique et des Libertés” CNIL Written consents were obtained from the mother for herself at inclusion and for her newborn child after deliveryWe are indebted to the participating families and to the midwife research assistants for data collection We acknowledge all the funding sources for the EDEN study Fondation pour la Recherche Médicale FRM French Ministry of Research IFR and Cohort program INSERM Nutrition Research Program French Ministry of Health Perinatality Program French Agency for Environment Security AFFSET French National Institute for Population Health Surveillance INVS Paris–Sud University French National Institute for Health Education INPES Nestlé Mutuelle Générale de l’Education Nationale MGEN French speaking association for the study of diabetes and metabolism Alfediam National Agency for Research ANR non thematic program National Institute for Research in Public Health IRESP TGIR cohorte santé 2008 program

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