Authors: Robert Stahl Sapna K Jain Jürgen Lutz Bradley T Wyman MariePierre Hellio Le GraverandGastineau Eric Vignon Sharmila Majumdar Thomas M Link
Publish Date: 2011/04/09
Volume: 40, Issue: 10, Pages: 1315-1327
Abstract
30 T MRI of the knee was performed in 60 women 30 with early OA each 15 with Kellgren–Lawrence grade 2 and 3 and 30 agematched controls at baseline and at 12 and 24 months Pathological condition was assessed with the wholeorgan magnetic resonance imaging score WORMS Cartilage abnormalities and bone marrow edema pattern BMEP were also quantified using a previously introduced morphological quantitative score These data were correlated with changes in clinical parameters and joint space width using generalized estimation equations GEEAt baseline OA patients had significantly p 005 more and larger cartilage lesions and BMEP During followup cartilage lesions increased significantly p 005 in the patients compared with controls WORMS showed progression only at the lateral patella whereas the quantitative score revealed progression additionally at the trochlea and at the medial compartment Both scores showed a significant p 005 increase in BMEP at the lateral femur in OA patients In addition quantitative scores of BMEP of the whole knee decreased significantly p 005 after 12 months and increased after 24 months in the patients but showed an increase in controls at all followup examinations Only weak correlations between structural imaging findings and clinical parameters were observedThis work was supported by Pfizer Inc Eastern Point Road Groton CT 06340 USA We are grateful to the dedicated group of A9001140 investigators Cecil Charles Julia Crim David Hunter Gary Hutchins Chris Jackson Virginia Byers Kraus Steve Mazzuca Prasad Pottumarthi Thomas Schnitzer Mihra Taljanovic and Berchman Vaz Also to the dedicated study coordinators whose skills were essential in ensuring the successful conduct of this research Emily Brown Sandra Chapman Eugene Dunkle Kristen Fredley Donna Gilmore Joyce Goggins Mohsen HaddadKaveh Norine Hall Thelma Munoz and Kim Tally We would also like to express our thanks to the dedicated MRI technologists the Duke Image Analysis Laboratory staff Cecil Charles Maureen Ainslie April Davis Allison Fowlkes Mark Ward Scott White and the Pfizer A9001140 Team Lydia Brunstetter Peggy Coyle Yevgenia Davidoff Charles Packard Ann Remmers Mark Tengowski Jeff Evelhoch now MerckWest Point PA USA and John Kotyk now Washington University St Louis MI USA
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