Authors: Roman Guggenberger Emrah Koral Wolfgang Zemann Christine Jacobsen Gustav Andreisek Philipp Metzler
Publish Date: 2014/07/05
Volume: 43, Issue: 12, Pages: 1669-1678
Abstract
A BRONJ 22 patients mean age 700 years group was age and gender matched to a healthy control group 22 patients mean age 680 years On CBCT images two independent readers performed quantitative bone density value BDV measurements with region and volumeofinterest ROI and VOI based approaches and qualitative scoring of BRONJassociated necrosis sclerosis and periosteal thickening 1 = not present to 5 = definitely present Intraoperative and clinical findings served as standard of reference Interreader agreements and diagnostic performance were assessed by intraclass correlation coefficients ICC kappastatistics and receiveroperating characteristic ROC analysisTwentythree regions in 22 patients were affected by BRONJ ICC values for mean BDV VOI and mean BDV ROI were 0864 and 0968 respectively p 0001 The area under the curve AUC for mean BDV VOI and mean BDV ROI was 058/083 with a sensitivity of 57/83 and specificity of 61/77 for diagnosis of BRONJ respectively Kappa values for presence of necrosis sclerosis and periosteal thickening were 0575 0617 and 0885 respectively AUC values for qualitative parameters ranged between 090–096 with sensitivity of 96 and specificities between 79–96 at respective cutoff scoresNo portion of the article is under consideration for publication elsewhere The submission of this manuscript has been approved by all authors and by institutions where the work has been carried out There are no violations of ethical standards or conflicts of interest None of the authors has financial interests in the subject matter
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