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Title of Journal: Skeletal Radiol

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Abbravation: Skeletal Radiology

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Springer Berlin Heidelberg

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DOI

10.1007/s12467-011-0017-4

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ISSN

1432-2161

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Effect of zoledronic acid on vertebral marrow adip

Authors: Yi Yang Xianfu Luo Fuhua Yan Zheng Jiang Yong Li Chen Fang Junkang Shen
Publish Date: 2015/07/01
Volume: 44, Issue: 10, Pages: 1499-1505
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Abstract

Zoledronic acid ZOL has a suppressive effect on marrow adiposity in ovariectomized rats Currently however data on the effect of ZOL on marrow fat in humans are unavailable The purpose of this work was to determine the in vivo effect of ZOL on bone remodeling and marrow adipogenesis in postmenopausal osteoporosisIn a 12month randomized doubleblind placebocontrolled trial we studied 100 postmenopausal women with osteoporosis who were randomly given either a single dose of intravenous infusion of ZOL 5 mg or placebo All subjects received adequate dietary calcium and vitamin D3 Main outcome measures included bone mineral density by dualenergy Xray absorptiometry vertebral marrow fat content by proton MR spectroscopy serum markers of bone turnover by biochemical analysisNinety percent of the participants completed the 12month followup With respect to baselines marrow fat content reduced by 81  in the ZOLtreated women and increased by 30  in the controls all p  005 In addition there were significant increases of bone mineral density by 28 20 and 17  in the lumbar spine femoral neck and total hip respectively in the ZOL group compared with the placebo group Serum levels of bone resorption marker CTX and bone formation marker BALP decreased by 33 and 18  in postmenopausal women receiving ZOL

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