Incidence of Red Cell Alloantibody among the Trans

Authors: Rabeya Yousuf Suria Abdul Aziz Nurasyikin Yusof Chooi Fun Leong

Publish Date: 2012/04/25

Volume: 29, Issue: 2, Pages: 65-70

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Abstract

Red blood cell alloimmunization is a common complication among the transfusion recipients In Malaysia multiple ethnicity causes genetic heterogeneity among the population which in turn can cause a wide variation of antibody The objective of this study was to analyse the red cell alloantibody detected during the pretransfusion testing This was a crosssectional study done in the blood bank of Universiti Kebangsaan Malaysia Medical Centre during the period of January–December 2010 The data was retrieved from the hospital laboratory information system A total of 24263 patients’ blood samples were subjected for pretransfusion testing Antibody screening was done using an indirect antiglobulin test method The positive samples were further identified for antibody specificity Antibody screening tests were positive in 184 patients out of 24263 samples with the incidence of 076  Autoantibodies and alloantibodies were detected in 39/184 212  and 140/184 761  of the patients respectively In five patients 27  the antibody specificity remained undetermined Total 161 alloantibodies were identified The suspected AntiMia alloantibody was observed most frequently 49/161 304  followed by antiE 30/161 186  and antiD 22/161 137  AntiE and antic were the most common combination of multiple alloantibodies In view of the high incidence of suspected AntiMia antibodies more efforts are needed to look into the techniques for confirmation of the AntiMia antibodies Besides that we suggested that all multiply transfused patients should be phenotyped for the Rh system and to supply Rh phenotype specific blood in order to limit alloimmunization

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