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Title of Journal: Indian J Hematol Blood Transfus

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Abbravation: Indian Journal of Hematology and Blood Transfusion

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Springer India

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DOI

10.1016/0924-977X(91)90489-H

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0974-0449

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CD56 Negative Aggressive T Cell Large Granular Lym

Authors: Mary Theresa Sylvia Sajini Elizabeth Jacob Debdatta Basu Deepak Amalnath Tarun Kumar Dutta
Publish Date: 2015/01/13
Volume: 32, Issue: 1, Pages: 121-124
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Abstract

T cell large granular lymphocytic leukemia is a clonal proliferation of cytotoxic large granular T cells positive for CD3 and CD8 It is a chronic lymphoproliferative disorder with an indolent course Therapeutic options include observation and low dose chemotherapy Rarely they have an aggressive course Such cases have expression of NK cell associated antigens like CD56 in the T cells These cases require more aggressive therapy with acute lymphoblastic leukemia regimens We report a case of fatal CD56 negative T cell large granular lymphocytic leukemia in a 38 year old lady

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