Authors: C Trillou J P Santoni JCh Friedmann
Publish Date: 2012/10/19
Volume: 7, Issue: 6, Pages: 323-330
Abstract
The gastric tolerability of low dose conventional aspirin acetylsalicylic acid was compared with that of lysine acetylsalicylate in the dog A total of 14 dogs were allocated to aspirin 250mg n = 2 or 500mg n = 4 tablets lysine acetylsalicylate powder LAS corresponding to 250mg aspirin n = 2 or to 500mg aspirin n = 4 and to plain vehicle n = 2 Animals were sacrificed after general anaesthesia Macro and microscopic examinations of gastric and duodenal mucosae were performed 3 or 5 hours after single dose oral administration No significant duodenal lesions were found On the gastric mucosa vascular changes oedema and microhaemorrhages and foveolar atrophy were observed with a similar frequency and intensity in all groups receiving aspirin or LAS Mucosal erosions with coagulative necrosis occurred only in the aspirin groups Thus the gastrotoxicity of aspirin at relatively low doses is apparent with a standard aspirin formulation but seems substantially less when using a highly soluble acetylsalicylate salt
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