Authors: Franco Dallegri L Ottonello F Gatti G Guidi
Publish Date: 2012/10/26
Volume: 3, Issue: 2, Pages: 71-74
Abstract
Nimesulide affects neutrophil behaviour during inflammatory reactions at 2 steps of the cell response It reduces oxidant production during neutrophil interaction with chemotactic factors celldirected action without affecting cell locomotory capacity and during phagocytosis celldirected action without limiting neutrophil ingestive efficiency In addition nimesulide acts as an inactivator of the hypochlorous acid generated during the phagocytic process scavenging action The drugconcentration threshold for the scavenging action of nimesulide 10−5 mol/L appears to be lower than that for the celldirected actions 5 × 10−5 mol/L As the celldirected actions result in reduction but not complete suppression of the cellresponding capacity downregulation neutrophils can be expected to maintain their ability to handle microorganisms as suggested by the lack of infection during nimesulide treatment On the other hand the control of neutrophil oxidative potential detected at drug concentrations achievable in plasma after oral administration is likely to contribute to the antiinflammatory activity of the drug by limiting the extracellular availability of toxic oxidants
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