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Title of Journal: Acta Neurol Belg

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Abbravation: Acta Neurologica Belgica

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Springer Milan

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DOI

10.1016/0025-3227(75)90044-4

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2240-2993

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Effect of lowfrequency stimulation on kindling in

Authors: Razieh Rohani Abbas Piryaei Ali Jahanshahi Yousef Sadeghi Javad MirnajafiZadeh
Publish Date: 2013/08/23
Volume: 114, Issue: 1, Pages: 47-53
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Abstract

It has been shown that lowfrequency stimulation LFS can induce anticonvulsant effects In this study the effect of different LFS frequencies on kindling induced behavioral and ultrastructural changes was investigated For induction of kindled seizures in rats stimulating and recording electrodes were implanted in perforant path and dentate gyrus respectively Animals were stimulated in a rapid kindling manner Different groups of animals received LFS at different frequencies 05 1 and 5 Hz following kindling stimulations and their effects on kindling rate were determined using behavioral and ultrastructural studies Kindling stimulations were applied for 7 days Then the animals were sacrificed and their dentate gyrus was sampled for ultrastructural studies under electron microscopy All three used LFS frequencies 05 1 and 5 Hz had a significant inhibitory effect on kindling rate and decreased afterdischarge duration and the number of stimulations to achieve stage 4 and 5 seizures significantly In addition application of LFS prevented the increase in the postsynaptic density and induction of concave synaptic vesicles following kindling There was no significant change between anticonvulsant effects of LFS at different frequencies Obtained results show that LFS application can prevent the neuronal hyperexcitability by preventing the ultrastructural changes during kindling and this may be one of the mechanisms of LFS anticonvulsant effects

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