Do evoked potentials contribute to the functional

Authors: Xavier Giffroy Nathalie Maes Adelin Albert Pierre Maquet JeanMichel Crielaard Dominique Dive

Publish Date: 2016/05/19

Volume: 117, Issue: 1, Pages: 53-59

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Abstract

The clinical variability and complexity of multiple sclerosis MS challenges the individual clinical course prognostication This study aimed to find out whether multimodal evoked potentials EP correlate with the motor components of multiple sclerosis functional composite MSFCm and predict clinically relevant motor functional deterioration One hundred MS patients were assessed at baseline T 0 and about 75 years later T 1 with visual somatosensory and motor EP and rated on the Expanded Disability Status Scale EDSS and the MSFCm including the 9 Hole Peg Test and the Timed 25 Foot Walk T25FW The Spearman correlation coefficient r S was used to evaluate the crosssectional and longitudinal relationship between EP Z scores and clinical findings The predictive value of baseline electrophysiological data for clinical worsening EDSS 9HPT T25FW MSFCm during followup was assessed by logistic regression analysis Unlike longitudinal correlations crosssectional correlations between EP Z scores and clinical outcomes were all significant and ranged between 022 and 067 p  005 The global EP Z score was systematically predictive of EDSS and MSFCm worsening over time all p  005 EP latency was a better predictor than amplitude although weaker than latency and amplitude aggregation in the global EP Z score The study demonstrates that EP numerical scores can be used for motor function monitoring and outcome prediction in patients with MSAll procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards For this type retrospective study of study formal consent is not requiredThe study was approved by the Local Ethics Committee University Hospital of Liege RéfB707201318670 Informed consent statement was provided by patients The study has been performed in accordance with the ICH International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines

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