Journal Title
Title of Journal: Chromosome Res
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Abbravation: Chromosome Research
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Publisher
Springer Netherlands
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Authors: Tarik Rakkaa Christophe Escudé Régis Giet Laura MagnaghiJaulin Christian Jaulin
Publish Date: 2014/01/17
Volume: 22, Issue: 3, Pages: 267-276
Abstract
The cyclindependent kinase CDK11p58 is specifically expressed at G2/M phase CDK11p58 depletion leads to different cell cycle defects such as mitotic arrest failure in centriole duplication and centrosome maturation and premature sister chromatid separation We report that upon CDK11 depletion loss of sister chromatid cohesion occurs during mitosis but not during G2 phase CDK11p58 depletion prevents Bub1 and Shugoshin 1 recruitment but has no effect on the dimethylation of histone H3 lysine 4 at centromeres We also report that a construct expressing a kinase dead version of CDK11p58 fails to prevent CDK11 depletioninduced sister chromatid separation showing that CDK11p58 kinase activity is required for protection of sister chromatid cohesion at centromeres during mitosis Thus CDK11p58 kinase activity appears to be involved in early events in the establishment of the centromere protection machinery
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