Authors: M Yu Zen’ko E A Rybnikova T S Glushchenko
Publish Date: 2015/09/26
Volume: 45, Issue: 8, Pages: 869-872
Abstract
Quantitative immunohistochemical studies of changes in the expression of the neurotrophin BDNF brainderived neurotrophic factor in the hippocampus and neocortex were performed in 24 male Wistar rats as they developed a poststress anxiety state in an experimental model of posttraumatic stress disorder and during correction of this condition by hypoxic postconditioning PostC The anxiety state was induced by combined psychoemotional stress restraint stress forced swimming ether stress and after seven days repeated restraint ie restress Correction of the anxiety state in the rats was with hypoxic postconditioning – three sessions of moderate hypobaric hypoxia 360 mmHg 2 h Formation of the anxiety state was accompanied by a significant reduction in the content of immunoreactive BDNF in the dorsal CA1 and ventral dentate gyrus hippocampus and the neocortex while hypoxic PostC led to partial hippocampus and complete neocortex restoration of BDNF expression The results provided evidence that neurotrophic factors particularly BDNF appear to play an important role in the pathogenesis of anxiousdepressive disorders and the realization of the proadaptive and neuroprotective actions of hypoxic PostC
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