Authors: N I Yarushkina T R Bagaeva L P Filaretova
Publish Date: 2016/04/04
Volume: 46, Issue: 4, Pages: 472-477
Abstract
Corticotrophinreleasing factor CRF is involved in regulating pain sensitivity and can elicit analgesic effects in animals and humans The aim of the present work was to investigate the involvement of types 1 and 2 CRF receptors CRF1 and CRF2 receptors in mediating the analgesic action of CRF on somatic pain sensitivity when given systemically to conscious rats Somatic pain sensitivity was tested in terms of the latent period LP of the tailflick reaction in response to thermal stimulation the tail flick test The involvement of CRF1 and CFR2 receptors was studied by systemic administration of their specific antagonists NBI 27914 and astressin 2B respectively Systemic administration of CRF increased the latent period of the pain reaction it had an analgesic effect Prior administration of NBI 27914 or astressin 2B eliminated the analgesic effect of CRF In addition administration of NBI 27914 affected the basal latent period of the pain reaction increasing it These data provide evidence that the analgesic effect of CRF may be mediated by both CRF1 and CRF2 receptors CRF1 receptors unlike CRF2 receptors may also be involved in regulating the basal level of pain sensitivity
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