Authors: Gang Wang Zhenzhou He
Publish Date: 2015/11/06
Volume: 39, Issue: 3, Pages: 197-200
Abstract
Plastic surgery patients frequently request extensive liposuction on approximately 30 of the total body surface area which indicates that the total dose of lidocaine used might exceed the recommended level Our previous study demonstrated that the risk of toxicity is low because the peak lidocaine level is below the toxic threshold 3 μg/mL However monoethylglycinexylidide MEGX the active metabolite of lidocaine has not been measured in extensive liposuction operationsTen female patients who requested extensive liposuction were enrolled in this study The targeted areas were divided into two segments and treated in turn for one session Serum levels of lidocaine and MEGX were taken every 4 h during the first 24 h after the second infiltrationThe peak lidocaine levels 194 ± 04 μg/mL were observed after 12–20 h 168 ± 253 h whereas the peak MEGX levels 067 ± 012 μg/mL were observed after 16–20 h 176 ± 207 h The peak concentrations of lidocaine plus MEGX 258 ± 047 μg/mL were observed after 172 ± 24 hThe authors thank Weigang Cao MD PhD Department of Reconstructive and Plastic surgery in Shanghai Ninth Peoples’ Hospital in performing extensive liposuction The authors thank Li Sun PhD Department of Pharmacy in Shanghai Renji Hospital in calibrating lidocaine and MEGX measurements in the plasma
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