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Title of Journal: NED TIJDSCHR DIABET

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Abbravation: Nederlands Tijdschrift voor Diabetologie

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Publisher

Bohn Stafleu van Loghum

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DOI

10.1016/0168-1923(86)90070-5

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ISSN

1876-6242

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PS5 28 Pioglitazone treatment improves muscle o

Authors: Bart Wessels Jolita Ciapaite Klaas Nicolay Jeanine Prompers
Publish Date: 2015/03/17
Volume: 9, Issue: 3, Pages: 109-110
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Abstract

Pioglitazone is a PPAR agonist that redirects lipids from ectopic sites into subcutaneous adipose tissue and is hypothesized to improve mitochondrial function in skeletal muscle This study assessed whether the insulinsensitizing effect of pioglitazone is accompanied by improved skeletal muscle mitochondrial function and intramyocellular lipid IMCL levels in Zucker diabetic fatty rats using 31P and 1H magnetic resonance spectroscopy MRS


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