Bacterial Virulence Factors Secreted for Survival

Authors: Aditya Kumar Sharma Neha Dhasmana Neha Dubey Nishant Kumar Aakriti Gangwal Meetu Gupta Yogendra Singh

Publish Date: 2016/11/05

Volume: 57, Issue: 1, Pages: 1-10

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Abstract

Virulence is described as an ability of an organism to infect the host and cause a disease Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level These factors are either secretory membrane associated or cytosolic in nature The cytosolic factors facilitate the bacterium to undergo quick adaptive—metabolic physiological and morphological shifts The membrane associated virulence factors aid the bacterium in adhesion and evasion of the host cell The secretory factors are important components of bacterial armoury which help the bacterium wade through the innate and adaptive immune response mounted within the host In extracellular pathogens the secretory virulence factors act synergistically to kill the host cells In this review we revisit the role of some of the secreted virulence factors of two human pathogens Mycobacterium tuberculosis—an intracellular pathogen and Bacillus anthracis—an extracellular pathogen The advances in research on the role of secretory factors of these pathogens during infection are discussedThis work is supported by Defense Research and Development Organization India Grant No LSRB268/BTB/2013 AKS SRF NK JRF AG JRF are supported by University Grant Commission India NDhasmana is supported by Council of Scientific and Industrial Research CSIRSPM SRF NDubey is supported by Indian Council of Medical Research ICMRSRF MG is supported by Council of Scientific and Industrial Research CSIRRA Authors are thankful to the Academy of Scientific and Innovative Research AcSIR New Delhi India

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