Promoter polymorphisms of Emphasis Type="Italic"

Authors: Hyun Kyung Park Su Kang Kim

Publish Date: 2016/01/07

Volume: 11, Issue: 4, Pages: 401-406

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Abstract

Benign prostatic hyperplasia BPH is considered the most common prostate disease in elderly men Recent studies have suggested that specific polymorphisms might be contributed to risk factors for development of BPH The aim of present study is to investigate whether promoter single nucleotide polymorphisms SNPs of the NDUFA4 mitochondrial complex associated NDUFA4 gene are risk factors for BPH in Korean men To evaluate the associations between promoter SNPs rs17163801 rs17163803 rs1681288 and rs3761817 of NDUFA4 gene and clinical progress of BPH one hundred eighty one BPH patients were recruited from Department of Urology at Kyung Hee Hospital Prostate volume international prostate symptom score IPSS and prostate specific antigen PSA were measured For genetic analysis SNPStats and SPSS 220 were performed Genetic models codominant dominant recessive and logadditive models were applied to calculate the odds ratio OR 95 confidence interval CI and P value Among tested four SNPs three promoter SNPs rs17163803 rs1681288 and rs3761817 showed significant associations with prostate volume after Bonferroni’s correction rs17163803 OR=300 95 CI=131684 P c=0036 in codominant 1 model rs1681288 OR=353 95 CI=165 756 P c=0004 in codominant 1 model OR=298 95 CI=147605 P c=00072 in dominant model rs3761817 OR=386 95 CI=179831 P c=0004 in codominant 1 model OR=325 95 CI=159 662 P c=00032 in dominant model OR=219 95 CI=121399 P c=00296 The results of present study demonstrate that specific promoter polymorphisms rs17163803 rs1681288 and rs3761817 of the NDUFA4 gene might be associated with prostate enlargement in Korean men

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