Differential Diagnosis of Melanoma Cells in Tissue

Authors: Y ROBERT BARISHAK

Publish Date: 1960/09/01

Volume: 64, Issue: 3, Pages: 367-376

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Abstract

Introduction  The differential diagnosis of melanoma cells in tissue cultures of uveal melanomas may present difficulties Their growth patterns and morphological characteristics were reported in the preceding paper1 but since the morphology is not always clearcut it was felt that the routine use of differential stains and histochemical reactions could be a valuable diagnostic adjunct In an effort to determine what stains and histochemical reactions might best be suited to this purpose a series of experiments was performed on melanoma cells from various sourcesIn addition to studies of variously stained preparations a special study of the use of silver stains was undertaken Of the many properties that have been used to identify melanin color site of formation state of aggregation mechanism of production nature of the chromagen solubility chemical reactivity composition none is specific2 The most reliable of these differentiating properties however is chemical reactivity ie the

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