Journal Title
Title of Journal: Arch Ophthalmol
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Abbravation: Archives of Ophthalmology
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Publisher
American Medical Association
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Authors: AUSTIN I FINK TOMOYA FUNAHASHI MARGARET ROBINSON R JANET WATSON
Publish Date: 1961/12/01
Volume: 66, Issue: 6, Pages: 824-829
Abstract
Introduction The development of a sicklecell crisis remains one of the most interesting and fundamentally unsolved problems of sicklecell disease12 Presumably the erythrocytes sickle in the small vessels where the oxygen tension is lower and one might expect a crisis to be accompanied by an increase in sickling in the vasculature of various parts of the body The crisis is often characterized by episodes of generalized pain associated with fever No hematological data exist which can be used to diagnose the presence of such a crisis One logical approach to investigating the mechanism of crisis would involve doing in vivo studies of the capillary circulation in sicklecell anemia patients in and out of crisis The bulbar conjunctiva lends itself ideally to such a study Scattered reports have described the occurrence and presented sketches of capillary dilatations in the conjunctiva of patients with either sicklecell anemia or hemoglobinC disease36
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References
citation title=Morphologic and Hemodynamic Changes in the Smaller Vessels in Diabetes Mellitus citation author=Ditzel J and Sagild UNew Engl J Med citation year=1954 citation volume=250 citation pages=587
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