Journal Title 
                                            
              Title of Journal: Arch Ophthalmol 
                                            
                                         
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              Abbravation: Archives of Ophthalmology 
                                            
                                         
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              American Medical Association 
                                            
                                         
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              Authors: AUSTIN I FINK TOMOYA FUNAHASHI MARGARET ROBINSON R JANET WATSON 
              Publish Date: 1961/12/01
              Volume: 66, Issue: 6, Pages: 824-829 
			  
              Abstract
              Introduction  The development of a sicklecell crisis remains one of the most interesting and fundamentally unsolved problems of sicklecell disease12 Presumably the erythrocytes sickle in the small vessels where the oxygen tension is lower and one might expect a crisis to be accompanied by an increase in sickling in the vasculature of various parts of the body The crisis is often characterized by episodes of generalized pain associated with fever No hematological data exist which can be used to diagnose the presence of such a crisis One logical approach to investigating the mechanism of crisis would involve doing in vivo studies of the capillary circulation in sicklecell anemia patients in and out of crisis The bulbar conjunctiva lends itself ideally to such a study Scattered reports have described the occurrence and presented sketches of capillary dilatations in the conjunctiva of patients with either sicklecell anemia or hemoglobinC disease36 
               
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        References
        
          citation title=Morphologic and Hemodynamic Changes in the Smaller Vessels in Diabetes Mellitus citation author=Ditzel   J and Sagild UNew Engl J Med  citation year=1954  citation volume=250  citation pages=587  
           
         
     
                             
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