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Abbravation: Bioscience Reports

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Portland Press Limited

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10.1007/bf01578671

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1573-4935

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Common action of certain viruses toxins and acti

Authors: C L Bashford G M Alder K Patel C A Pasternak
Publish Date: 1984/09/01
Volume: 4, Issue: 9, Pages: 797-805
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Abstract

Haemolysis by Sendal virus αtoxin and activated complement is inhibited by high concentrations of divalent cations In Daudi cells sublytic amounts of these agents induce the following changes collapse of surface membrane potential uptake of Na+ and loss of K+ from cells and leakage of phosphorylated metabotites from cells The changes induced by Sendal virus and complement are sensitive to physiological concentrations of extracellular Ca2+ It is concluded that fluctuations in plasma Ca2+ concentration may affect the damaging action of certain poreforming agents on susceptible cells

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