Authors: Maitreyi Nag Namita Nandi
Publish Date: 1987/09/01
Volume: 7, Issue: 9, Pages: 701-704
Abstract
Chloropromazine CPZ and imipramine at a concentration of 1×10−3 M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55 respectively while lithium even at a concentration of 005 M inhibits the activity of this enzyme very negligibly 4 In vivo these drugs at a dose level of 56 mg CPZ 76 mg Jimipramine and 76 mg lithium chloride/Kg body wt did not cause any observable variation from normal in brain mitochondrial monoamine oxidase activity
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