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Abbravation: Bioscience Reports

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Portland Press Limited

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10.1007/bf01493739

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1573-4935

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Heat shock proteins induce pores in membranes

Authors: G M Alder B M Austen C L Bashford A Mehlert C A Pasternak
Publish Date: 1990/12/01
Volume: 10, Issue: 6, Pages: 509-518
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Abstract

Human heat shock protein hsp 70 and bacterial protein groEL promote leakage of calcein from liposomes induced by human serum albumin signal peptide by S aureus α toxin or by diphtheria toxin Hsp 70 and groEL as well as two mycobacterial homologues hsp 71 and hsp 65 induce ion conducting pores across planar lipid bilayers at low or neutral pH It is concluded that hsp induce pores in membranes and that this may contribute to their action within cells


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