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Title of Journal: Ann Biomed Eng

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Abbravation: Annals of Biomedical Engineering

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Springer US

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DOI

10.1007/s11128-012-0448-x

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ISSN

1573-9686

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Nanoscale Intracellular Organization and Functiona

Authors: Philip P LeDuc Robert R Bellin
Publish Date: 2006/02/03
Volume: 34, Issue: 1, Pages: 102-113
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Abstract

Cells function based on a complex set of interactions that control pathways resulting in ultimate cell fates including proliferation differentiation and apoptosis The interworkings of this immensely dense network of intracellular molecules are influenced by more than random protein and nucleic acid distribution where their interactions culminate in distinct cellular function By probing the design of these biological systems from an engineering perspective researchers can gain great insight that will aid in building and utilizing systems that are on this size scale where traditional largescale rules may fail to apply The organized interaction and gradient distribution in intracellular space imply a structural architecture that modulates cellular processes by influencing biochemical interactions including transport and bindingreactions One significant structure that plays a role in this modulation is the cell cytoskeleton Here we discuss the cytoskeleton as a central and integrating functional structure in influencing cell processes and we describe technology useful for probing this structure We explain the nanometer scale science of cytoskeletal structure with respect to intracellular organization mechanotransduction cytoskeletalassociated proteins and motor molecules as well as nano and microtechnologies that are applicable for experimental studies of the cytoskeleton This biological architecture of the cytoskeleton influences molecular cellular and physiological processes through structured multimodular and hierarchical principles centered on these functional filaments Through investigating these organic systems that have evolved over billions of years understanding in biology engineering and nanometerscaled science will be advancedThis work was supported in part by grants from the National Science Foundation RB National Science FoundationCAREER PL Pennsylvania Infrastructure Technology Alliance and the Department of EnergyGenome to Life Program The authors would also like to thank M L Ledbetter S LeDuc S Lawrence and W Messner for their helpful discussions and input on the manuscript

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