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Title of Journal: Ann Biomed Eng

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Abbravation: Annals of Biomedical Engineering

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Springer US

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DOI

10.1016/j.ajog.2008.09.265

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1573-9686

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HSubscript2/SubscriptOSubscript2/Subscript

Authors: Sing Wan Wong Shan Sun Michael Cho Kenneth K H Lee Arthur F T MAK
Publish Date: 2014/11/05
Volume: 43, Issue: 5, Pages: 1178-1188
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Abstract

Skeletal muscles often experience oxidative stress in anaerobic metabolism and ischemia–reperfusion This paper reports how oxidative stress affects the stiffness of cultured murine myotubes and their actin filaments polymerization dynamics H2O2 was applied as an extrinsic oxidant to C2C12 myotubes Atomic force microscopy results showed that short exposures to H2O2 apparently increased the stiffness of myotubes but that long exposures made the cells softer The turning point seemed to take place somewhere between 1 and 2 h of H2O2 exposure We found that the stiffness change was probably due to actin filaments being favored for depolymerization after prolong H2O2 treatments especially when the exposure duration exceeded 1 h and the exposure concentration reached 10 mM Such depolymerization effect was associated with the downregulation of thymosin beta 4 as well as the upregulation of both cofilin2 and profilin1 after prolong H2O2 treatments

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