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Title of Journal: Ann Biomed Eng

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Abbravation: Annals of Biomedical Engineering

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Springer US

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DOI

10.1002/cite.201050234

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1573-9686

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Tissue Engineering and Regenerative Repair in Woun

Authors: Michael S Hu Zeshaan N Maan JenChieh Wu Robert C Rennert Wan Xing Hong Tiffany S Lai Alexander T M Cheung Graham G Walmsley Michael T Chung Adrian McArdle Michael T Longaker H Peter Lorenz
Publish Date: 2014/05/01
Volume: 42, Issue: 7, Pages: 1494-1507
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Abstract

Wound healing is a highly evolved defense mechanism against infection and further injury It is a complex process involving multiple cell types and biological pathways Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation In contrast early to midgestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation This early observation has led to extensive research seeking to unlock the mechanism underlying fetal scarless regenerative repair Building upon recent advances in biomaterials and stem cell applications tissue engineering approaches are working towards a recapitulation of this phenomenon In this review we describe the elements that distinguish fetal scarless and adult scarring wound healing and discuss current trends in tissue engineering aimed at achieving scarless tissue regeneration

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