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Title of Journal: Ann Biomed Eng

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Abbravation: Annals of Biomedical Engineering

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Springer US

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DOI

10.1001/jama.2009.678

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1573-9686

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Upregulation of SDF1 is Associated with Atheroscl

Authors: Dangheng Wei Guixue Wang Chaojun Tang Juhui Qiu Jingbo Zhao Hans Gregersen Linhong Deng
Publish Date: 2012/01/04
Volume: 40, Issue: 5, Pages: 1018-1027
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Abstract

Previous numerical simulations on lowdensity lipoprotein LDL concentration polarization in the arterial system indicated that LDL concentration polarization might play an important role in the genesis and development of atherosclerosis To date no in vivo experiments have examined this question directly and the molecular mechanisms are unknown In this study ten rabbits were treated with gel–silica loop to develop a defined local stenosis in the straight segment of the left carotid artery Both numerical simulation and experiment measurements showed that the concentration of LDL was about 35 higher at the blood/arterial wall interface than in the lumen on the distal side of the stenosis Atherosclerotic lesions with abundant lipid deposits were observed and stromal derived factor1 SDF1 was detected at the distal end of the stenosis while the straight segment was plaquefree In vitro studies demonstrated that LDLinduced SDF1 expression in endothelial cells and increased monocyte adhesion to endothelial cells in a dosedependent manner The adhesion was suppressed when endothelial cells were pretreated with SDF1 antibody These results suggested LDL concentration polarization contributed to the localization of atherosclerosis and to the expression of SDF1 In turn SDF1 facilitated plaque formation

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