Authors: Ryogo Minamimoto Nobukazu Takahashi Tomio Inoue
Publish Date: 2007/06/25
Volume: 21, Issue: 4, Pages: 217-
Abstract
This study aims to clarify the effect of renal function on 218F fluoro2deoxydglucose positron emission tomography FDGPET imaging and determine the clinical significance of renal function in this setting We compared FDG distribution between normal volunteers and patients with suspected renal failureTwenty healthy volunteers and 20 patients with suspected renal failure who underwent FDGPET between November 2002 and May 2005 were selected for this study We define “patients with suspected renal failure” as having a blood serum creatinine level in excess of 11 mg/dl The serum creatinine level was examined once in 2 weeks of the FDGPET study Regions of interest were placed over 15 regions for semiquantitative analysis the white matter cortex both upper lung fields both middle lung fields both lower lung fields mediastinum myocardium of the left ventricle the left atrium as a cardiac blood pool central region of the right lobe of the liver left kidney and both femoris musclesThe mean standardized uptake values SUVs of brain cortex and white matter were higher in healthy volunteers than in renal patients The mean SUVs of the mediastinum at the level of the aortic arch and left atrium as a cardiac blood pool were lower in healthy volunteers than in patients with suspected renal failure These regions differed between healthy volunteers and patients with suspected renal failure P 005We found decreasing brain accumulation and increasing blood pool accumulation of FDG in patients with high plasma creatinine Although the difference is small this phenomenon will not have a huge effect on the assessment of FDGPET imaging in patients with suspected renal failure
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