The clinical application value of PET/CT in adenoc

Authors: Songtao Liu Hongxia Cheng Shuzhan Yao Caixia Wang Guangxiu Han Xin Li Cheng Liu

Publish Date: 2010/07/08

Volume: 24, Issue: 7, Pages: 541-547

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Abstract

The goal of our study was to demonstrate the clinical usefulness of positron emission tomography/computed tomography PET/CT for adenocarcinoma with bronchioloalveolar carcinoma BAC features through evaluating the relationship between the intrathoracic lymph node metastases and maximum standardized uptake value SUVmax tumor size of the primary tumor and the ratio of BAC component and analysing the correlation of SUVmax tumor size and the ratio of BAC componentThis was a retrospective study Fortyfive patients with focal peripheral lung adenocarcinoma with BAC features were included in this study and underwent the PET/CT scan Twentyone patients were women and 24 were men None of the patients had insulindependent diabetes and the serum glucose levels in all patients just before 18FFDG was injected were less than 120 mg/dl The diagnosis of the lesion was made by surgical histopathologyAll patients underwent successful surgery and pathologic examination confirmed that 34 of 118 excised nodal groups in 18 patients were proved to be positive for malignancy Univariate analysis revealed 3 potential factors related to intrathoracic lymph node metastases SUVmax P = 0002 the ratio of BAC component P = 0002 maximum dimension of a tumor on mediastinal window setting images mDmax P = 0025 The maximum dimension of a tumor on pulmonary window setting images pDmax P = 0373 had no significance A receiver operating characteristic ROC curve based on SUVmax mDmax and the ratio of BAC component was constructed the area under curve AUC was 852 703 and 815 separately There was no statistical significance between AUC of SUVmax and AUC of the ratio of BAC component Z = 0901 P = 0368 The AUC of SUVmax and AUC of the ratio of BAC component were significantly higher than AUC of mDmax Z = 2112 P = 0035 Z = 2016 P = 0042The SUVmax and the ratio of BAC component had significant inverse correlation r = −085 P  001 The mDmax and the ratio of BAC component had significant inverse correlation r = −069 P  001 The SUVmax and mDmax had significant correlation r = 060 P  001

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