Journal Title
Title of Journal: Ann Nucl Med
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Abbravation: Annals of Nuclear Medicine
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Authors: Yoo Sung Song So Won Oh Yu Keong Kim SeungKi Kim KyuChang Wang Dong Soo Lee
Publish Date: 2011/10/28
Volume: 26, Issue: 1, Pages: 47-57
Abstract
The reinforcement of the anterior cerebral artery ACA territory perfusion is important for the future intellectual functioning of pediatric moyamoya disease MMD patients To evaluate the hemodynamic improvement of the ACA territory bifrontal encephalogaleoperiostealsynangiosis EGPS combined with encephaloduroarteriosynangiosis EDAS was compared with EDAS alone in pediatric MMD patients using brain perfusion SPECTAmong 36 patients MF = 1620 mean age 95 ± 30 years who were surgically treated for MMD EDAS was performed in 17 patients and EDAS with bifrontal EGPS in 19 patients Hemodynamic parameters consisting of basal cerebral perfusion acetazolamidechallenge stress perfusion and cerebrovascular reserve index were estimated using brain perfusion SPECT and probabilistic perfusion maps for the ACA and middle cerebral artery MCA territories Cerebral angiography was performed to confirm revascularizationBoth the EDAS only p = 004 and EDAS with EGPS group p 0001 had significant improvements in cerebrovascular reserve of the ipsilateral MCA territory The EDAS with EGPS group had significant improvements not only in basal perfusion of the ipsilateral ACA territory p = 003 but also in the cerebrovascular reserve of the bilateral ACA territories p 001 In parallel with the hemodynamic changes assessed by brain perfusion SPECT neovascularization was noted in the ipsilateral MCA territory in both the EDAS only and EDAS with EGPS group and in the ipsilateral ACA territory in the EDAS with EGPS group on the postoperative cerebral angiographyThis study was funded by the Brain Research Center of the 21st Century Frontier Research Program 2009K001257 the WCU project of the MEST and the NRF R312008000101030 and the Korea Healthcare technology RD Project Ministry for Health Welfare Family Affairs Republic of Korea A08058826 SK K
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