First experience with early dynamic Superscript1

Authors: Martin Freesmeyer Franz F Stecker JanHenning Schierz Gunther O Hofmann Thomas Winkens

Publish Date: 2014/01/29

Volume: 28, Issue: 4, Pages: 314-321

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Abstract

This study investigates whether early dynamic positron emission tomography/computed tomography edPET/CT using 18Fsodium fluoride18FNaF is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis COMA total of 12 ed18FNaFPET/CT examinations were performed on 11 consecutive patients 2 female 9 male age 53 ± 12 years in list mode over 5 min starting with radiopharmaceutical injection before standard late 18FNaFPET/CT Eight consecutive time intervals frames were reconstructed for each patient four 15 s then four 60 s Several volumes of interest VOI were selected representing the affected area as well as different reference areas within the bone and soft tissue Maximum and mean ed standardized uptake values edSUVmax edSUVmean respectively were calculated in each VOI during each frame to measure early fluoride influx and accumulation Results were compared between affected and nonaffected contralateral bonesStarting in the 31–45 s frame the affected bone area showed significantly higher edSUVmax and edSUVmean compared to the healthy contralateral region The affected bone areas also significantly differed from nonaffected contralateral regions in conventional late 18FNaFPET/CTThis pilot study suggests that in patients with COM ed18FNaF PET offers additional information about early radiotracer distribution to standard 18FNaF PET/CT similar to a threephase bone scan The results should be validated in larger trials which directly compare ed18FNaFPET to a threephase bone scanThe authors thank Dr Dominik Driesch BioControl Jena GmbH Jena Germany for statistical analysis and Dr Thomas Grüning Derriford Hospital Plymouth Devon PL6 8DH United Kingdom for adding useful remarks on the evaluation of our data Furthermore Prof Dr Andreas Tiemann Department of Trauma and Reconstructive Surgery Bergmannstrost Hospital Halle Germany is gratefully acknowledged for providing patient data This study was funded from the Jena University Hospital budget

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