Authors: Martin Freesmeyer Christian Kühnel Julian G Westphal
Publish Date: 2014/09/14
Volume: 29, Issue: 1, Pages: 8-14
Abstract
Benign thyroid diseases are widely common in western societies However the volumetry of the thyroid gland especially when enlarged or abnormally formed proves to be a challenge in clinical routine The aim of this study was to develop a simple and rapid thresholdbased isocontour extraction method for thyroid volumetry from 124IPET/CT data in patients scheduled for radioactive iodine therapyPET/CT data from 45 patients were analysed 30 h after 1 MBq 124I administration Anatomical reference volume was calculated using manually contoured data from lowdose CT images of the neck MC In addition we applied an automatic isocontour extraction method IC02/10 with two different threshold values 02 and 10 kBq/ml for volumetry of the PET dataset IC02/10 shape data that showed significant variation from MC data were excluded Subsequently a mathematical correlation using a model of linear regression with multiple variables and stepwise elimination mIC02/10 between IC02/10 and MC was establishedContour extraction with both mIC10 and mIC02 gave rapid and reliable results However mIC02 can be applied to significantly more patients 90 and is therefore deemed to be more suitable for clinical routine keeping in mind the potential advantages of using 124IPET/CT for the preparation of patients scheduled for radioactive iodine therapyThe authors are grateful to Mr Dominik Driesch for statistical work and careful examination of the data presented in this publication Furthermore we would like to thank ASK Scientific for providing services in translation and reviewing the manuscript carefully
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