Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Biol Inorg Chem

Search In Journal Title:

Abbravation: JBIC Journal of Biological Inorganic Chemistry

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1007/s11109-011-9165-x

Search In DOI:

ISSN

1432-1327

Search In ISSN:
Search In Title Of Papers:

Folding of the prion peptide GGGTHSQW around the c

Authors: Christelle Hureau Christelle Mathé Peter Faller Tony A Mattioli Pierre Dorlet
Publish Date: 2008/05/24
Volume: 13, Issue: 7, Pages: 1055-
PDF Link

Abstract

The GGGTHSQW sequence in the amyloidogenic part of the prion protein is a potential binding site for CuII We have previously studied the binding of copper to the shorter GGGTH peptide and showed that it is highly pH dependent Hureau et al in J Biol Inorg Chem 11735–744 2006 Two predominant complexes could be characterized at pH 67 and 90 with equatorial binding modes of 3N1O and 4N for the metal ion respectively In this work we have further investigated the coordination of CuII to the GGGTH peptide as well as the longer GGGTHSQW peptide in order to identify the oxygen donor ligand at neutral pH and to study the proximity and redox activity of the tryptophan residue of the latter The results for both peptides show that at pH 67 CuII is coordinated by a carbonyl peptide backbone At higher pH values the carbonyl ligand dissociates and the coordination changes to a 4N binding mode inducing a structural rearrangement that brings the GGGTHSQW peptide’s tryptophan residue into the vicinity of the copper ion thus affecting their respective redox propertiesThis work was supported by a grant from the Agence Nationale de la Recherche Programme Jeunes Chercheuses Jeunes Chercheurs ANR05JCJC0010 ‘NEUROARPE’ to PD including a postdoctoral fellowship to CM We thank Guillaume Blain for technical assistance and maintenance of the Elexys EPR/ENDOR spectrometer Emmanuelle Mothes and Luc Guilloreau for fluorescence measurements Jérôme Santolini for assistance with the ATRFTIR measurements Alain Boussac for the use of the pulsedEPR spectrometer and Elodie AnxolabéhèreMallart for discussions


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. The Fox1 ferroxidase of Chlamydomonas reinhardtii : a new multicopper oxidase structural paradigm
  2. Impaired hydrolysis of cisplatin derivatives to aquated species prevents energy-dependent uptake in GLC4 cells resistant to cisplatin
  3. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
  4. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
  5. New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer
  6. Effect of complex formation between Zn 2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase
  7. DNA targeting and cleavage by an engineered metalloprotein dimer
  8. Cobalt hexaamine mediated electrocatalytic voltammetry of dimethyl sulfoxide reductase: driving force effects on catalysis
  9. Ciliate metallothioneins: unique microbial eukaryotic heavy-metal-binder molecules
  10. Structural and thermodynamical properties of Cu II amyloid- β 16/28 complexes associated with Alzheimer’s disease
  11. Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals
  12. The role of axial ligands for the structure and function of chlorophylls
  13. Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis
  14. Synthesis and crystal structures of novel copper(II) complexes with glycine and substituted phenanthrolines: reactivity towards DNA/BSA and in vitro cytotoxic and antimicrobial evaluation
  15. Enantiopure copper(II) complex of natural product rosin derivative: DNA binding, DNA cleavage and cytotoxicity
  16. Human copper transporter Ctr1 is functional in Drosophila , revealing a high degree of conservation between mammals and insects
  17. A spectroscopic and voltammetric study of the pH-dependent Cu(II) coordination to the peptide GGGTH: relevance to the fifth Cu(II) site in the prion protein
  18. Kinetic and structural studies on roles of the serine ligand and a strictly conserved tyrosine residue in nitrile hydratase
  19. A realistic in silico model for structure/function studies of molybdenum–copper CO dehydrogenase
  20. Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates
  21. A systematic investigation of multiheme c -type cytochromes in prokaryotes
  22. Protein stability and mutations in the axial methionine loop of a minimal cytochrome c

Search Result: